Large Volume, Behaviorally-relevant Illumination for Optogenetics in Non-human Primates.

Dissecting neural circuits for vision in non- human primates using fMRI-guided electrophysiology and optogenetics

A precise and minimally invasive approach to optogenetics in the awake primate

Optogenetics has proven to be a powerful tool for understanding the function of specific cell types and circuits within the central nervous system and establishing a causal link between their activity and behavior. Its application in non-human primates has been slow to develop. One challenge has been the damage caused by transdural delivery of viruses and light to the brain. Here, we report opt...

Neural coding of behavioral relevance in parietal cortex.

Flexible control of behavior requires the selective processing of task-relevant sensory information and the appropriate linkage of sensory input to action. A great deal of evidence suggests a central role for the parietal cortex in these functions. Recent results from neurophysiological studies in non-human primates and neuroimaging experiments in humans illuminate the importance of parietal co...

Optogenetics through windows on the brain of primates

25 Optogenetics combines optics and genetics to control neuronal activity with cell-type 26 specificity and millisecond temporal precision. Its use in model organisms such as 27 rodents, drosophila, and C. Elegans is now well established. However, application of 28 this technology in non-human primates (NHP) has been slow to develop. One key 29 challenge has been the delivery of viruses and lig...

Editorial: What can simple brains teach us about how vision works

Vision is the process of extracting behaviorally-relevant information from patterns of light that fall on retina as the eyes sample the outside world. Traditionally, non-human primates have been viewed by many as the animal model-of-choice for investigating the neuronal substrates of visual processing, not only because their visual systems closely mirror our own (e.g., Orban, 2008; Nassi and Ca...